Name | Brompheniramine hydrogen maleate |
Synonyms | dimegan dimotane dimetane dimetanemaleate Brompheniramine Maleate RS-brompheniramine maleate Brompheniramine hydrogen maleate g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate |
CAS | 980-71-2 |
EINECS | 213-562-9 |
InChI | InChI=1/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
InChIKey | SRGKFVAASLQVBO-BTJKTKAUSA-N |
Molecular Formula | C20H23BrN2O4 |
Molar Mass | 435.31 |
Melting Point | 134-135°C |
Boling Point | 403°C at 760 mmHg |
Flash Point | 9℃ |
Solubility | Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. |
Vapor Presure | 1.05E-06mmHg at 25°C |
Appearance | neat |
Color | White to Off-White |
Maximum wavelength(λmax) | ['261nm(lit.)'] |
Merck | 14,1443 |
Storage Condition | Inert atmosphere,Room Temperature |
Use | A histamine H1 receptors antagonist |
In vitro study | In in vitro experiments, Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells, sodium and calcium channels in CHO cells, as well as potassium channels in human embryonic kidney 293 (HEK-293) cells. Brompheniramine suppresses the transfected Nav 1.5 channels from myocytes. |
In vivo study | Brompheniramine as an antihistamine blocks sodium channels. Brompheniramine (3.0, 1.5, 1.1, 0.6, and 0.3 μmol) treatment shows cutaneous analgesic effect with an ED 50 value of 0.89 in a rat model of infiltration anesthesia. Subcutaneous Brompheniramine induces dose-relatedly analgesic effects, and Brompheniramine induces prolonged analgesic duration. |
Risk Codes | R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
UN IDs | 3249 |
WGK Germany | 3 |
RTECS | US4025000 |
TSCA | Yes |
HS Code | 38220090 |
Hazard Class | 6.1(b) |
Packing Group | III |